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  丁显廷

  万象城娱乐allwincity体育特聘教授、博士生导师，个性化医学研究院常务副院长、万象城娱乐allwincity体育分子与纳米医学平台主任。国家科技创新领军人才、国家海外高层次人才、国家优秀青年科学基金、国家重点实验室PI、求是基金会“求是杰出青年学者奖”、广慈基金会“转化医学创新奖”、唐仲英基金会“仲英青年学者”、中国抗癌协会青年科学家奖、上海市“曙光计划”学者、上海市科协“飞翔计划”学者、上海市优秀党外双创人才、万象城娱乐allwincity体育“凯原十佳教师“、世界经济论坛（World Economic Forum, WEF）青年科学家、世界顶尖科学家论坛（World Laureates Forum, WLF）青年科学家、美国南加州中华科学家工程师协会青年科学家、微纳系统与工程(Microsystems & Nanoengineering, MINE) Young Scientist Award、国际实验室自动化与筛查协会(Society for Laboratory Automatiom and Screening, SLAS) Tony B. Academic Award、iCANX Young Scientist Award。

  
  

          担任比尔.盖茨基金会(Bill & Melinda Gates Foundation)国际重大专项负责人、国家”重大新药创制“科技重大专项负责人、国家重点研发计划”生物安全技术“专项负责人、科技部中国APEC国际合作项目负责人、军委科技委国防创新特区第一批启动项目负责人、国家重点研发计划”前沿和共性技术创新“课题负责人、国家“艾滋病和病毒性肝炎等重大传染病防治”重大科技专项课题负责人、国际人类表型组计划课题负责人、上海市科技创新行动计划负责人、国家自然基金项目负责人等。

  
  

          担任6个国际SCI期刊的编委会成员，已发表包括Nature, Genome Biology, Advanced Materials, Angew Chemie, Science Advances, Nature Communications, PNAS, Nature Protocols, ACS Nano在内的国际期刊论文180余篇，授权国内外发明专利80余项。

  
  

  研究方向：

  1. 单细胞时空蛋白组学技术、生物信息学大数据分析 和 人工智能建模；

  2. 基于功能材料的微量蛋白组、修饰化蛋白组的富集分离纯化技术；

  3. 基于单细胞技术的重大疾病（癌症、代谢性疾病、心脑疾病、神经系统疾病等）的早期预警研究；

  4. 痕量临床样本（单细胞）蛋白检验新装置的集成化和微型化（科学仪器研制、微流控技术、生物传感技术）。

民盟中央委员；民盟上海市委员；民盟万象城娱乐allwincity体育副主委；上海市徐汇区政协委员。

中央JW科技委GF科技创新特区变革性交叉科学技术领域专家组专家委员、中国妇幼保健协会青年工作委员会医教研产一体化协作组副组长、全国肿瘤人工智能专业委员会委员、全国发酵工程技术工作委员会智能制造专业委员会委员、全国卫生产业协会实验医学专家委员会青年委员会委员、世界华人医师协会前沿科技与临床转化专业委员会委员、上海市免疫学会免疫遗传专业委员会常务委员、上海市药学会药物治疗专业委员会委员、上海医学会神经免疫学会委员、中国医药生物技术技术协会生物安全专业委员会委员。

担任法国国家科研署（ANR）国际通讯评审、澳大利亚国立健康与医学研究理事会（NHMRC）国际通讯评审、以色列科技部（MOST Israel）国际通讯评审、波兰国家科学中心（NCN）国际通讯评审、塞尔维亚科学基金会（Science Fund of the Republic of Serbia）、UK Pancreatic Cancer Research Fund (英国慈善科研机构)、Bill & Melinda Gates Foundation（美国慈善科研机构）国际通讯评审。

研究方向：

1. 单细胞时空蛋白组学技术、生物信息学大数据分析 和 人工智能建模；

2. 基于功能材料的微量蛋白组、修饰化蛋白组的富集分离纯化技术；

3. 基于单细胞技术的重大疾病（癌症、代谢性疾病、心脑疾病、神经系统疾病等）的早期预警研究；

4. 痕量临床样本（单细胞）蛋白检验新装置的集成化和微型化（科学仪器研制、微流控技术、生物传感技术）。

实验室主页 ： http://www.dinglab.com.cn/

1. Jingqi Dang, Hongxia Li, Lulu Zhang, Sijie Li, Ting Zhang, Shiyi Huang, Yiyang Li, Chengjie Huang, Yuqing Ke, Guangxia Shen*, Xiao Zhi* and Xianting Ding*, New Structure Mass Tag based on Ab functionalized Zr-NMOF in Mass Cytometry for Multiparameter and Sensitive Single-Cell Biomarker Interrogating, Advanced Materials, 2021, 202008297

2. Shanhe Li#, Ze Wen, Behafarid Ghalandari, Tianhao Zhou, Antony R. Warden, Ting Zhang, Peng Dai, Youyi Yu, Wenke Guo, Mofang Liu, Haiyang Xie*, and Xianting Ding*, Single-cell transfection analysis chip enables high-throughput screening and accurate profiling of exogenous gene expression in single host cells, Advanced Materials, 2021, 2101108

3. Rui Chen, Jiasu Xu, Boqian Wang, Yi Ding, Aynur Abdulla, Yiyang Li, Lai Jiang, Xianting Ding*. SpiDe-Sr: blind super-resolution network for precise cell segmentation and clustering in spatial proteomics imaging, Nature Communications, 2024, 15:2708

4.Shuang Zhang, Behafarid Ghalandari, Youming Chen, Qingwen Wang, Kun Liu, Xinyi Sun, Xinwen Ding, Sunfengda Song, Lai Jiang, and Xianting Ding*. Boronic Acid-Rich Lanthanide Metal-Organic Frameworks Enable Deep Proteomics with Ultratrace Biological Samples. Advanced Materials, 2024, 2401559

5.Qingwen Wang, Xinwen Ding, Zhixiao Xu, Boqian Wang, Aiting Wang, Liping Wang, Yi Ding, Fengda Songsun, Youming Chen, Shuang Zhang, Lai Jiang, Xianting Ding*. The mouse multi-organ proteome from infancy to adulthood, Nature Communications, 2024, (2024) 15:5752

6.Yuqing Ke#, Shiyi Huang, Behafarid Ghalandari, Sijie Li, Antony R Warden, Jingqi Dang, Lin Kang, Yu Zhang, Yunqing Wang, Yiqing Sun, Jinglin Wang, Daxiang Cui , Xiao Zhi*, Xianting Ding*, Hairpin-spacer crRNA enhanced CRISPR/Cas13a system promotes the specificity of single nucleotide polymorphisms (SNPs) identification, Advanced Science, 2021, 2003611 

7.Shuang Zhang, Behafarid Ghalandari, Aiting Wang, Sijie Li, Youming Chen, Qingwen Wang, Lai Jiang, Xianting Ding*. Superparamagnetic Composite Nanobeads Anchored with Molecular Glues for Ultrasensitive Label-free Proteomics, Angew. Chem. Int. Ed., 2023, e202309806

8.Ting Zhang, Shanhe Li, Antony R. Warden, Behafarid Ghalandari, Hongxia Li, Xiao Zhi, Haiyang Xie*, and Xianting Ding*, A Photoclick Hydrogel for Enhanced Single-cell Immunoblotting, Advanced Functional Materials, 2020, 10, 1002: 1910739

9.Hanyu Rao, Changwei Liu, Aiting Wang, Chunxiao Ma, Yue Xu, Tianbao Ye, Wenqiong Su, Peijun Zhou, Wei-Qiang Gao, Li Li*, Xianting Ding*. SETD2 Deficiency Accelerates Sphingomyelin Accumulation and Promotes the Development of Renal Cancer, Nature Communications, 2023, (2023) 14:7572

10. Yu Zhang#, Antony R. Warden, Khan Zara Ahmad, Yanlei Liu, Xijun He, Minqiao Zheng, Xinlong Huo, Xiao Zhi, Yuqing Ke, Hongxia Li, Sijia Yan, Wenqiong Su, Deng Cai, Xianting Ding*. Single-Cell Microwell Platform Reveals Circulating Neural Cells as a Clinical Indicator for Patients with Blood-Brain Barrier Breakdown, Research, 2021: 9873545

11.Xiao Liu#, Weichen Song#, Brandon Yi-ning Wong, Ting Zhang, Shunying Yu, Guan Ning Lin*, Xianting Ding*, A comparison framework and guideline of clustering methods for mass cytometry data, Genome Biology, 2019, (2019) 20:297

12. Yilin Cai#, Shiyi Huang#, Zhinan Zhang*, Jiazheng Zhang, Xingyue Zhu, Xiaoxiang Chen, Xianting Ding*. Bioinspired Rotation Microneedles for Accurate Transdermal Positioning and Ultra-Minimal-Invasive Biomarker Detection with Mechanical Robustness, Research, 2022, 2022(5):1-15

13. Hongxia Li#, Antony R. Warden, Jie He, Guangxia Shen*, Xianting Ding*. Expansion Microscopy with Nine-fold Swelling (NIFS) Hydrogel Permits Cellular Ultrastructure Imaging on Conventional Microscope, Science Advances,2022, abm4003

14. Xianting Ding*, Zach Njus, Taejoon Kong, Wenqiong Su, Chih-Ming Ho and Santosh Pandey*, Effective drug combination for Caenorhabditis elegans nematodes discovered by output-driven feedback system control technique, Science Advances, 2017,3(10):eaao1254

15. Lulu Zhang#, Xiao Liu#, Xiaoxiang Chen, Antony R Warden, Youyi Yu, Baozhen Huang, Xianting Ding*. SCANCell reveals diverse inter-cluster interaction patterns in systemic lupus erythematosus across the disease spectrum, Bioinformatics, 2021, Volume 38, Issue 5, Pages 1361–1368

16.Youyi Yu#, Xin Wang#, Xiaolong Jia, Lulu Zhang, Hongxia Li, Jie He, Guangxia Sheng*, Xianting Ding*. Aptamer Probes Labeled with Lanthanide-Doped Carbon Nanodots permit Dual-Modal Fluorescence and Mass Cytometric Imaging, Advanced Science, 2021, 2102812

17.Haiyang Xie#, Wenke Guo#, Hui Jiang#, Ting Zhang#, Lei Zhao, Jinjuan Hu, Shuxin Gao, Sunfengda Song, Jiasu Xu, Li Xu, Xinyi Sun, Yi Ding, Lai Jiang and Xianting Ding*. Photosensitive hydrogel with temperature-controlled reversible nano-apertures for single-cell protein analysis, Advanced Science, 2024,e2308569

18.Shuang Zhang, Zhixiao Xu, Youming Chen, Lai Jiang, Aiting Wang, Guangxia Shen, and Xianting Ding*. Lanthanide Metal−Organic Framework Flowers for Proteome Profiling and Biomarker Identification in Ultratrace Biofluid Samples, ACS Nano, 2025, 19(4):4377-4390

19. Haoni Yan, Aynur Abdulla, Aiting Wang, Shuyu Ding, Manlin Zhang, Yizhi Zhang,Tsz Yui Zhuang, Leqi Wu, Yan Wang, Rongrong Ren,* Lai Jiang,* and Xianting Ding*. Time-Lapse Acquisition of Both Freely Secreted Proteomeand Exosome Encapsulated Proteome in Live Organoids’ Microenvironment, Advanced Science, 2024, 2406509

20. Jie He, Hengyu Li*, John Mai, Yuqing Ke, Chunhui Zhai, Jiao Jiao Li, Lai Jiang, Guangxia Shen*, Xianting Ding*. Profiling extracellular vesicle surface proteins with 10 µL peripheral plasma within 4 h, Journal of Extracellular Vesicles, 2023, 12(9):e12364